Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MC4R | P32245 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8033218 | 0.92 | SIGMAR1 (0.49) | SIGMAR1ALDH1A1DRD4KDM4ENPC1 | |
| SCHEMBL8029636 | 0.83 | SIGMAR1 (0.59) | SIGMAR1ALDH1A1DRD4KDM4ENPC1 | |
| SCHEMBL8031456 | 0.78 | PPARG (0.55) | SIGMAR1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL8020027 | 0.77 | SIGMAR1 (0.55) | SIGMAR1ALDH1A1KDM4ENPC1TP53 | |
| SCHEMBL8029641 | 0.76 | ALDH1A1 (0.65) | SIGMAR1ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL17861674 | 0.75 | PPARA (0.49) | ALDH1A1MEN1KMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL8020121 | 0.74 | SIGMAR1 (0.56) | SIGMAR1ALDH1A1DRD4KDM4ENPC1 | |
| SCHEMBL8035713 | 0.73 | MAPK1 (0.57) | SIGMAR1ALDH1A1DRD4KDM4ENPC1 | |
| SCHEMBL13036529 | 0.70 | SIGMAR1 (0.69) | SIGMAR1ALDH1A1DRD4KDM4EKMT2A | |
| SCHEMBL20090429 | 0.70 | SIGMAR1 (0.62) | SIGMAR1ALDH1A1DRD4KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0702010-B1 | Benzopyranderivatives, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2000-03-15 | — | — | EP | disclosed |
| US-5668138-A | AFFINITY FOR SIGMA RECEPTORS, CENTRAL NERVOUS SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 1997-09-16 | — | — | US | disclosed |
| EP-0702010-A1 | Benzopyranderivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-03-20 | — | — | EP | disclosed |