Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | ITK | Q08881 | 4/20 | 0.33 |
| ▸ | EGFR | P00533 | 3/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | BTK | Q06187 | 3/20 | 0.31 |
| ▸ | CDK14 | O94921 | 1/20 | 0.30 |
| ▸ | CCNY | Q8ND76 | 1/20 | 0.30 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16994112 | 0.79 | CHRNB2 (0.33) | CHRNB2CHRNB4CHRNA3CHRNA4JAK3 | |
| SCHEMBL7928560 | 0.78 | CHRNB2 (0.55) | CHRNB2CHRNB4CHRNA3CHRNA4ITK | |
| SCHEMBL27451892 | 0.78 | CHRNB2 (0.55) | CHRNB2CHRNB4CHRNA3CHRNA4ITK | |
| SCHEMBL20425354 | 0.78 | CHRNB2 (0.55) | CHRNB2CHRNB4CHRNA3CHRNA4ITK | |
| SCHEMBL20206293 | 0.78 | CHRNB2 (0.37) | CHRNB2CHRNB4CHRNA3CHRNA4ITK | |
| SCHEMBL23336220 | 0.77 | CHRNB2 (0.36) | CHRNB2CHRNB4CHRNA3CHRNA4ITK | |
| SCHEMBL19890610 | 0.77 | CHRNB2 (0.36) | CHRNB2CHRNB4CHRNA3CHRNA4ITK | |
| SCHEMBL16665104 | 0.77 | CHRNB2 (0.36) | CHRNB2CHRNB4CHRNA3CHRNA4ITK | |
| SCHEMBL12831951 | 0.76 | JAK3 (0.33) | CHRNB2CHRNB4CHRNA3CHRNA4ITK | |
| SCHEMBL9070554 | 0.75 | ALDH1A1 (0.37) | CHRNB2CHRNB4CHRNA3CHRNA4ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010129053-A2 | EGFR INHIBITORS AND METHODS OF TREATING DISORDERS | DANA FARBER CANCER INSTITUTE (US) | 2010-11-11 | — | — | WO | disclosed |
| WO-2009082701-A1 | HCV PROTEASE INHIBITORS AND USES THEREOF | AVILA THERAPEUTICS, INC. (US) | 2009-07-02 | — | — | WO | disclosed |