Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.33 |
| ▸ | ITK | Q08881 | 2/20 | 0.32 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8031100 | 0.80 | ALDH1A1 (0.50) | CHRNB2CHRNB4CHRNA3CHRNA4TAS1R3 | |
| SCHEMBL25947506 | 0.80 | ALDH1A1 (0.50) | CHRNB2CHRNB4CHRNA3CHRNA4TAS1R3 | |
| SCHEMBL8031532 | 0.78 | CHRNB2 (0.35) | CHRNB2CHRNB4CHRNA3CHRNA4ITK | |
| SCHEMBL23095392 | 0.77 | CHRNB2 (0.40) | CHRNB2CHRNB4CHRNA3CHRNA4TAS1R3 | |
| SCHEMBL20807998 | 0.77 | CHRNB2 (0.40) | CHRNB2CHRNB4CHRNA3CHRNA4TAS1R3 | |
| SCHEMBL19119593 | 0.77 | CHRNB2 (0.40) | CHRNB2CHRNB4CHRNA3CHRNA4TAS1R3 | |
| SCHEMBL20132733 | 0.76 | TAS1R3 (0.42) | CHRNB2CHRNB4CHRNA3CHRNA4TAS1R3 | |
| SCHEMBL20715990 | 0.75 | CHRNB2 (0.38) | CHRNB2CHRNB4CHRNA3CHRNA4TAS1R3 | |
| SCHEMBL24603042 | 0.73 | TAS1R3 (0.47) | CHRNB2CHRNB4CHRNA3CHRNA4TAS1R3 | |
| SCHEMBL23336220 | 0.72 | CHRNB2 (0.36) | CHRNB2CHRNB4CHRNA3CHRNA4ITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3544970-B1 | INHIBITORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES AND USES THEREOF | DANA FARBER CANCER INST INC (US) | 2021-11-17 | — | — | EP | disclosed |
| WO-2018098367-A1 | INHIBITORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-05-31 | — | — | WO | disclosed |