Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 5/20 | 0.63 |
| ▸ | SRC | P12931 | 2/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | ESR1 | P03372 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.47 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.46 |
| ▸ | TNF | P01375 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclopropane SCHEMBL27385567 | 0.95 | CCR2 (0.58) | CCR2SRCCYP19A1SMN1; SMN2KDM4E | |
| SCHEMBL31402270 | 0.79 | CCR2 (0.59) | CCR2SRCCYP19A1SMN1; SMN2KDM4E | |
| SCHEMBL4802191 | 0.79 | CCR2 (0.59) | CCR2SRCCYP19A1SMN1; SMN2KDM4E | |
| SCHEMBL6821030 | 0.78 | HDAC1 (0.62) | CCR2CYP19A1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL18258132 | 0.78 | CCR2 (0.58) | CCR2CYP19A1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL17060338 | 0.78 | CCR2 (0.58) | CCR2CYP19A1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL30049411 | 0.78 | HDAC1 (0.62) | CCR2CYP19A1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL8802854 | 0.77 | CCR2 (0.54) | CCR2CYP19A1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL5378162 | 0.77 | CCR2 (1.00) | CCR2SRCALDH1A1PLA2G10GPR35 | |
| SCHEMBL4887683 | 0.76 | L3MBTL1 (0.61) | CCR2CYP19A1SMN1; SMN2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999044604-A9 | PHARMACEUTICAL COMPOSITIONS CONTAINING THE PHOSPHOLIPASE INHIBITOR SODIUM [[3-(2-AMINO-1,2-DIOXOETHYL)-2-ETHYL-1-PHENYLMETHYL)-1H-INDOL-4-YL]OXY]ACETATE | SHIONOGI & CO (JP) | 2000-01-20 | — | — | WO | disclosed |