Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.38 |
| ▸ | RELA | Q04206 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8051066 | 0.86 | RAB9A (0.44) | ALDH1A1LMNATP53SMN1; SMN2NPC1 | |
| SCHEMBL8048297 | 0.83 | HDAC6 (0.45) | POLBUSP2ALDH1A1LMNATP53 | |
| SCHEMBL8034295 | 0.83 | NPC1 (0.42) | POLBUSP2ALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL8042810 | 0.83 | ALDH1A1 (0.43) | PKMUSP2TSHRALDH1A1LMNA | |
| SCHEMBL8050828 | 0.83 | ALDH1A1 (0.48) | POLBPKMUSP2TSHRALDH1A1 | |
| SCHEMBL8042886 | 0.82 | KDM4E (0.44) | POLBTSHRALDH1A1LMNAKDM4E | |
| SCHEMBL8042762 | 0.81 | NPC1 (0.41) | USP2TSHRALDH1A1LMNATP53 | |
| SCHEMBL8032670 | 0.80 | ALDH1A1 (0.51) | PKMTSHRALDH1A1LMNAKDM4E | |
| SCHEMBL8051230 | 0.80 | TP53 (0.46) | PKMUSP2TSHRALDH1A1LMNA | |
| SCHEMBL8050797 | 0.80 | MAPK1 (0.40) | USP2TSHRALDH1A1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |