Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 6/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.38 |
| ▸ | TP53 | P04637 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8034295 | 0.90 | NPC1 (0.42) | NPC1KMT2AALDH1A1MAPTHTT | |
| SCHEMBL8032670 | 0.89 | ALDH1A1 (0.51) | KMT2AALDH1A1MAPTLMNAHTT | |
| SCHEMBL8042886 | 0.88 | KDM4E (0.44) | NPC1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL8045074 | 0.87 | RAB9A (0.41) | NPC1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL8033862 | 0.86 | POLB (0.47) | NPC1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL8049035 | 0.84 | L3MBTL1 (0.39) | NPC1KMT2AALDH1A1MAPTLMNA | |
| SCHEMBL8051066 | 0.84 | RAB9A (0.44) | NPC1ALDH1A1MAPTLMNAHTT | |
| SCHEMBL8042742 | 0.84 | ALDH1A1 (0.39) | NPC1KMT2AALDH1A1MAPTHTT | |
| SCHEMBL8050828 | 0.83 | ALDH1A1 (0.48) | KMT2AALDH1A1MAPTLMNAHTT | |
| SCHEMBL8710516 | 0.82 | RAB9A (0.37) | NPC1KMT2AKDM4CALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |