Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 8/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.39 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.39 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8048177 | 0.78 | RAB9A (0.37) | MAPTKDM4EKMT2AHPGD | |
| SCHEMBL8044098 | 0.78 | POLB (0.35) | MAPT | |
| SCHEMBL8050345 | 0.70 | KMT2A (0.38) | ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL722595 | 0.70 | CYP2A6 (0.56) | CYP2A6CYP3A4CYP2C19CYP2B6CYP2D6 | |
| SCHEMBL13130594 | 0.68 | CYP2A6 (0.61) | CYP2A6CYP3A4CYP2C19CYP2B6CYP2D6 | |
| SCHEMBL7818670 | 0.65 | KDM4E (0.41) | CYP2A6CYP3A4CYP2C19CYP2B6CYP2D6 | |
| SCHEMBL9465414 | 0.65 | CYP2A6 (0.44) | CYP2A6CYP3A4CYP2C19CYP2B6CYP2D6 | |
| SCHEMBL1425244 | 0.64 | CYP2A6 (0.62) | CYP2A6CYP3A4CYP2C19CYP2B6CYP2D6 | |
| SCHEMBL1821918 | 0.63 | CYP2A6 (0.60) | CYP2A6CYP3A4CYP2C19CYP2B6CYP2D6 | |
| SCHEMBL8076141 | 0.63 | CYP2A6 (0.55) | CYP2A6CYP3A4CYP2C19CYP2B6CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |