Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.48 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.45 |
| ▸ | ALPL | P05186 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044703 | 0.88 | MAPT (0.44) | KDM4ESMN1; SMN2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8045818 | 0.86 | HPGD (0.51) | SMN1; SMN2ALDH1A1HTTLMNAMAPT | |
| SCHEMBL8044465 | 0.86 | ALDH1A1 (0.51) | KDM4ESMN1; SMN2ALDH1A1HTTLMNA | |
| SCHEMBL8046081 | 0.86 | ALDH1A1 (0.46) | KDM4ESMN1; SMN2ALDH1A1HTTLMNA | |
| SCHEMBL8042658 | 0.85 | KMT2A (0.42) | SMN1; SMN2ALDH1A1HTTLMNAMAPT | |
| SCHEMBL8033656 | 0.85 | ALDH1A1 (0.41) | KDM4ESMN1; SMN2ALDH1A1HTTLMNA | |
| SCHEMBL8047631 | 0.85 | MAPT (0.41) | KDM4ESMN1; SMN2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8044841 | 0.82 | KDM4E (0.49) | KDM4ESMN1; SMN2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8048031 | 0.82 | PTGS2 (0.45) | SMN1; SMN2ALDH1A1HTTLMNAMAPT | |
| SCHEMBL8046366 | 0.80 | PTGS2 (0.50) | KDM4ESMN1; SMN2CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |