Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8051833 | 0.86 | POLB (0.54) | POLBSMN1; SMN2TSHRLMNAHPGD | |
| SCHEMBL8045341 | 0.81 | ALDH1A1 (0.49) | SMN1; SMN2TSHRLMNAHPGDHSD17B10 | |
| SCHEMBL8041886 | 0.80 | SMN1; SMN2 (0.45) | POLBSMN1; SMN2TSHRLMNAHPGD | |
| SCHEMBL8042328 | 0.80 | HSD17B10 (0.48) | POLBSMN1; SMN2TSHRLMNAHSD17B10 | |
| SCHEMBL8051265 | 0.80 | TP53 (0.41) | POLBSMN1; SMN2TSHRLMNAHPGD | |
| SCHEMBL8034317 | 0.79 | HPGD (0.51) | POLBSMN1; SMN2TSHRLMNAHPGD | |
| SCHEMBL8041793 | 0.79 | POLB (0.43) | POLBSMN1; SMN2TSHRLMNAHPGD | |
| SCHEMBL8033936 | 0.78 | ALDH1A1 (0.42) | POLBSMN1; SMN2TSHRLMNAHPGD | |
| SCHEMBL8032703 | 0.78 | KMT2A (0.44) | POLBSMN1; SMN2TSHRLMNAHPGD | |
| SCHEMBL8042498 | 0.77 | GAA (0.47) | POLBSMN1; SMN2TSHRLMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |