Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | TSHR | P16473 | 4/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | UBE2M | P61081 | 1/20 | 0.43 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8033936 | 0.92 | ALDH1A1 (0.42) | SMN1; SMN2ALDH1A1TSHRNPSR1MAPT | |
| SCHEMBL8048723 | 0.91 | VCP (0.48) | SMN1; SMN2ALDH1A1TSHRNPSR1MAPT | |
| SCHEMBL8043200 | 0.87 | ALDH1A1 (0.43) | SMN1; SMN2ALDH1A1TSHRNPSR1MAPT | |
| SCHEMBL8044812 | 0.85 | ALDH1A1 (0.52) | SMN1; SMN2ALDH1A1TSHRNPSR1MAPT | |
| SCHEMBL8045341 | 0.84 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1TSHRNPSR1MAPT | |
| SCHEMBL8033835 | 0.80 | POLB (0.41) | SMN1; SMN2ALDH1A1TSHRNPSR1MAPT | |
| SCHEMBL8052209 | 0.80 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1TSHRNPSR1MAPT | |
| SCHEMBL8037043 | 0.79 | SMN1; SMN2 (0.39) | SMN1; SMN2ALDH1A1TSHRNPSR1MAPT | |
| SCHEMBL8043675 | 0.79 | KIT (0.39) | ALDH1A1POLBHSD17B10L3MBTL1TDP1 | |
| SCHEMBL8044443 | 0.78 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1TSHRNPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |