Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPFFR1 | Q9GZQ6 | 2/20 | 0.45 |
| ▸ | NPFFR2 | Q9Y5X5 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8120081 | 1.00 | NPFFR1 (0.45) | NPFFR1NPFFR2GAAKDRTDP1 | |
| SCHEMBL8879892 | 0.90 | GAA (0.43) | GAATDP1MAPTKDM4E | |
| SCHEMBL8879894 | 0.90 | GAA (0.43) | GAATDP1MAPTKDM4E | |
| SCHEMBL29079163 | 0.85 | GAA (0.44) | GAATDP1MAPT | |
| SCHEMBL8997541 | 0.85 | NPFFR2 (0.45) | NPFFR1NPFFR2GAAKDRTDP1 | |
| SCHEMBL8997535 | 0.85 | NPFFR2 (0.45) | NPFFR1NPFFR2GAAKDRTDP1 | |
| SCHEMBL28449048 | 0.83 | GAA (0.50) | GAATDP1MAPTKDM4E | |
| SCHEMBL3311082 | 0.80 | NPFFR1 (0.43) | NPFFR1NPFFR2GAAKDRNOTUM | |
| SCHEMBL8880883 | 0.77 | ALDH1A1 (0.46) | GAATDP1HDAC1HDAC8HDAC6 | |
| SCHEMBL8880889 | 0.77 | ALDH1A1 (0.46) | GAATDP1HDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891322-B1 | DIMETHYL-SUBSTITUTED CYCLOHEXANE DIENE DERIVATIVES | BAYER AG (DE) | 2000-12-27 | — | — | EP | disclosed |
| US-6103925-A | MUSCLE CONTRACTION INHIBITORS; MODULATOR WITH SELECTIVITY FOR CHARYBDOTOXIN-SENSITIVE, CALCIUM-DEPENDENT POTASSIUM CHANNELS | BAYER AKTIENGESELLSCHAFT (DE) | 2000-08-15 | — | — | US | disclosed |
| EP-0758648-B1 | Substituted 4H-pyrans with a modulating effect on calcium channels | BAYER AG (DE) | 2000-03-15 | — | — | EP | disclosed |
| US-5760073-A | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | BAYER AKTIENGESELLSCHAFT (DE) | 1998-06-02 | — | — | US | disclosed |
| EP-0758648-A1 | Substituted 4H-pyrans with a modulating effect on calcium channels | BAYER AG (DE) | 1997-02-19 | — | — | EP | disclosed |