Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8879892 | 1.00 | GAA (0.43) | GAATDP1MAPTHTTHPGD | |
| SCHEMBL8034221 | 0.90 | NPFFR1 (0.45) | GAATDP1MAPTKDM4E | |
| SCHEMBL8120081 | 0.90 | NPFFR1 (0.45) | GAATDP1MAPTKDM4E | |
| SCHEMBL8918971 | 0.85 | ALDH1A1 (0.41) | GAATDP1MAPTHTTKDM4E | |
| SCHEMBL8918957 | 0.85 | ALDH1A1 (0.41) | GAATDP1MAPTHTTKDM4E | |
| SCHEMBL28449048 | 0.83 | GAA (0.50) | GAATDP1MAPTHPGDKDM4E | |
| SCHEMBL29079163 | 0.83 | GAA (0.44) | GAATDP1MAPTHPGD | |
| SCHEMBL8880883 | 0.77 | ALDH1A1 (0.46) | GAATDP1KDM4EALDH1A1 | |
| SCHEMBL8880889 | 0.77 | ALDH1A1 (0.46) | GAATDP1KDM4EALDH1A1 | |
| SCHEMBL6959838 | 0.76 | GAA (0.47) | GAAMAPTHTTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5652251-A | 6-amino-1,4-dihydropyridine compounds as medicaments for treatment of the central nervous system, and processes for their preparation | BAYER AKTIENGESELLSCHAFT (DE) | 1997-07-29 | — | — | US | disclosed |
| EP-0704434-A1 | 6-Amino-1,4-dihydropyridines and their use as selective k-channel modulators | BAYER AG (DE) | 1996-04-03 | — | — | EP | disclosed |