Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 6/20 | 0.43 |
| ▸ | CA2 | P00918 | 6/20 | 0.43 |
| ▸ | CA9 | Q16790 | 5/20 | 0.43 |
| ▸ | CA4 | P22748 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 6/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8047063 | 0.90 | TSHR (0.51) | HSD17B10KDM4ENPSR1SMN1; SMN2TSHR | |
| SCHEMBL8042509 | 0.88 | HSD17B10 (0.47) | PTGS2HSD17B10KDM4ENPSR1SMN1; SMN2 | |
| SCHEMBL8050842 | 0.86 | HSD17B10 (0.46) | PTGS2HSD17B10KDM4ENPSR1SMN1; SMN2 | |
| SCHEMBL8047548 | 0.86 | NPSR1 (0.54) | PTGS2HSD17B10KDM4ENPSR1SMN1; SMN2 | |
| SCHEMBL8047020 | 0.86 | RECQL (0.47) | PTGS2HSD17B10KDM4ENPSR1SMN1; SMN2 | |
| SCHEMBL8044326 | 0.86 | NPSR1 (0.47) | PTGS2HSD17B10KDM4ENPSR1SMN1; SMN2 | |
| SCHEMBL8043781 | 0.83 | TSHR (0.48) | HSD17B10KDM4ENPSR1SMN1; SMN2TSHR | |
| SCHEMBL8048223 | 0.81 | HSD17B10 (0.45) | PTGS2HSD17B10KDM4ENPSR1SMN1; SMN2 | |
| SCHEMBL8042898 | 0.80 | PTGS2 (0.43) | PTGS2PTGS1HSD17B10KDM4ENPSR1 | |
| SCHEMBL8044639 | 0.80 | HDAC6 (0.49) | HSD17B10KDM4ENPSR1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |