Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CDC7 | O00311 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8053191 | 0.84 | SIRT2 (0.53) | PLAUNPC1RAB9AMEN1KMT2A | |
| SCHEMBL8049631 | 0.82 | MEN1 (0.53) | NPC1MEN1KMT2AAGTR1MAPT | |
| SCHEMBL8047377 | 0.80 | KMT2A (0.49) | MEN1KMT2AAGTR1MAPTKDM4E | |
| SCHEMBL8044536 | 0.80 | NPC1 (0.44) | NPC1RAB9AMEN1KMT2AAGTR1 | |
| SCHEMBL8053284 | 0.79 | MEN1 (0.51) | NPC1RAB9AMEN1KMT2AAGTR1 | |
| SCHEMBL8045002 | 0.78 | ALDH1A1 (0.48) | NPC1RAB9AMEN1KMT2AAGTR1 | |
| SCHEMBL11465968 | 0.76 | MEN1 (0.57) | PLAUNPC1RAB9AMEN1KMT2A | |
| SCHEMBL8049795 | 0.76 | ALDH1A1 (0.44) | NPC1RAB9AMEN1KMT2AAGTR1 | |
| SCHEMBL1425720 | 0.75 | PTGER1 (0.56) | PLAUNPC1RAB9AKMT2A | |
| SCHEMBL8432960 | 0.73 | MEN1 (0.56) | RAB9AMEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0789020-B1 | Process for producing dioxoquinazolines | SUMITOMO CHEMICAL CO (JP) | 2000-04-12 | — | — | EP | disclosed |
| US-5780628-A | Process for producing dioxoquinazolines | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1998-07-14 | — | — | US | disclosed |
| EP-0789020-A1 | Process for producing dioxoquinazolines | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1997-08-13 | — | — | EP | disclosed |