SCHEMBL8036223

SCHEMBL8036223

CN(C(=O)COc1cccc(N(CC2CC2)C(=O)CNC(=O)Nc2cccc(CC(=O)O)c2)c1)c1ccccc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR3 P51677 2/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
PDE5A O76074 1/20 0.37
MAPK1 P28482 2/20 0.37
PPIB P23284 1/20 0.36
HTR2A P28223 1/20 0.36
TP53 P04637 2/20 0.36
HTT P42858 2/20 0.36
NPC1 O15118 1/20 0.36
RAB9A P51151 1/20 0.36
PTGIR P43119 1/20 0.36
HPSE Q9Y251 1/20 0.36
MLYCD O95822 1/20 0.36
TBXA2R P21731 1/20 0.36
KMT2A Q03164 2/20 0.36
MEN1 O00255 1/20 0.36
GAA P10253 1/20 0.36
GHSR Q92847 1/20 0.36
KLKB1 P03952 1/20 0.36
NTSR1 P30989 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8020810 0.96 CNR1 (0.38) CCR3SMN1; SMN2PDE5AHTR2ATP53
SCHEMBL8034174 0.90 ACHE (0.40) CCR3SMN1; SMN2PDE5AMAPK1PPIB
SCHEMBL8020823 0.89 SMN1; SMN2 (0.40) SMN1; SMN2PDE5AMAPK1PPIBTP53
SCHEMBL8036336 0.89 ACHE (0.40) CCR3SMN1; SMN2HTR2ATP53MLYCD
SCHEMBL8033859 0.89 SMN1; SMN2 (0.44) SMN1; SMN2PDE5AMAPK1PPIBTP53
SCHEMBL8033897 0.88 KMT2A (0.43) CCR3SMN1; SMN2MAPK1PPIBHTR2A
SCHEMBL8029991 0.88 LTB4R (0.41) SMN1; SMN2PDE5AMAPK1PPIBTP53
SCHEMBL8030178 0.87 MLYCD (0.39) SMN1; SMN2PDE5AMAPK1PPIBTP53
SCHEMBL8036230 0.87 SMN1; SMN2 (0.39) SMN1; SMN2PDE5AMAPK1PPIBTP53
SCHEMBL8031809 0.87 PPIB (0.38) SMN1; SMN2PDE5AMAPK1PPIBTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0985660-A1 AMINOPHENOL DERIVATIVES DAIICHI PHARMACEUTICAL CO., LTD. (JP) 2000-03-15 EP disclosed