Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8038252 | 0.96 | ACHE (0.32) | ACHECHRNB2CHRNA4CYP1A2CYP2A6 | |
| Hydrochloric Acid SCHEMBL6858841 | 0.76 | ACHE (0.32) | ACHECHRNB2CHRNA4CYP1A2CYP2A6 | |
| Hydrochloric Acid SCHEMBL9440609 | 0.76 | ACHE (0.32) | ACHECHRNB2CHRNA4CYP1A2CYP2A6 | |
| Hydrochloric Acid SCHEMBL8024803 | 0.76 | BRD4 (0.44) | CYP1A2CYP2A6 | |
| SCHEMBL8766062 | 0.75 | ACHE (0.35) | ACHECHRNB2CHRNA4CYP1A2CYP2A6 | |
| SCHEMBL29476027 | 0.75 | ACHE (0.35) | ACHECHRNB2CHRNA4CYP1A2CYP2A6 | |
| Hydrochloric Acid SCHEMBL8034594 | 0.75 | — | — | |
| Hydrochloric Acid SCHEMBL16144805 | 0.74 | HTR2C (0.31) | ACHECHRNB2CHRNA4CYP1A2CYP2A6 | |
| Hydrochloric Acid SCHEMBL1685523 | 0.74 | ACHE (0.31) | ACHECHRNB2CHRNA4CYP1A2CYP2A6 | |
| SCHEMBL24455618 | 0.73 | CHRNB2 (0.36) | ACHECHRNB2CHRNA4CYP1A2CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0796875-B1 | Process for the preparation of crystalline vinylaromatic polymers with a predominant syndiotactic structure | ENICHEM SPA (IT) | 2000-03-29 | — | — | EP | disclosed |
| US-5721327-A | Process for the preparation of crystalline vinylaromatic polymers with a predominant syndiotactic structure | ENICHEM S.P.A. (IT) | 1998-02-24 | — | — | US | disclosed |
| EP-0796875-A2 | Process for the preparation of crystalline vinylaromatic polymers with a predominant syndiotactic structure | ENICHEM S.p.A. (IT) | 1997-09-24 | — | — | EP | disclosed |