Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TK1 | P04183 | 2/20 | 0.35 |
| ▸ | PPID | Q08752 | 1/20 | 0.35 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2619884 | 1.00 | SMN1; SMN2 (0.38) | SMN1; SMN2POLBALDH1A1TSHRMEN1 | |
| SCHEMBL18011761 | 0.85 | NPSR1 (0.36) | POLBALDH1A1TSHRTK1LMNA | |
| SCHEMBL11296399 | 0.85 | NPSR1 (0.36) | POLBALDH1A1TSHRTK1LMNA | |
| SCHEMBL2932652 | 0.84 | TSHR (0.36) | POLBALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL20875702 | 0.84 | TSHR (0.36) | POLBALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL3078236 | 0.78 | SMN1; SMN2 (0.49) | SMN1; SMN2POLBALDH1A1TSHRMEN1 | |
| SCHEMBL4535689 | 0.77 | SMN1; SMN2 (0.41) | SMN1; SMN2POLBALDH1A1TSHRMEN1 | |
| SCHEMBL21764294 | 0.76 | PTPN1 (0.38) | ALDH1A1MEN1KMT2A | |
| SCHEMBL11027048 | 0.76 | PTPN1 (0.38) | ALDH1A1MEN1KMT2A | |
| SCHEMBL20096959 | 0.76 | TK1 (0.33) | POLBMEN1KMT2AABCB1TK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009091016-A1 | CONDENSED AMINODIHYDROTHIAZINE DERIVATIVE | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2009-07-23 | — | — | WO | disclosed |