SCHEMBL3078236

SCHEMBL3078236

CCOC(=O)COC(c1ccccc1)(c1ccccc1)c1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.49
POLB P06746 1/20 0.48
ABCB1 P08183 1/20 0.46
PPID Q08752 1/20 0.45
MEN1 O00255 1/20 0.45
KMT2A Q03164 1/20 0.45
HSD11B1 P28845 1/20 0.44
KDM4E B2RXH2 2/20 0.43
ALDH1A1 P00352 2/20 0.43
NLRP3 Q96P20 2/20 0.43
TSHR P16473 1/20 0.43
CASP3 P42574 1/20 0.43
CASP7 P55210 1/20 0.43
CASP9 P55211 1/20 0.43
TP53 P04637 1/20 0.43
MAPT P10636 1/20 0.43
HPGD P15428 1/20 0.43
HSD17B10 Q99714 1/20 0.43
PIN1 Q13526 1/20 0.42
USP2 O75604 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7923207 0.86 TK2 (0.44) SMN1; SMN2POLBABCB1PPIDMEN1
SCHEMBL10334914 0.85 POLB (0.50) SMN1; SMN2POLBABCB1PPIDMEN1
SCHEMBL4535689 0.82 SMN1; SMN2 (0.41) SMN1; SMN2POLBABCB1PPIDMEN1
SCHEMBL2822033 0.82 KCNN4 (0.48) SMN1; SMN2POLBMEN1KMT2AKDM4E
SCHEMBL7054160 0.82 KIF11 (0.47) MEN1KMT2AALDH1A1TSHRMAPT
SCHEMBL10334637 0.81 SMN1; SMN2 (0.48) SMN1; SMN2POLBPPIDMEN1KMT2A
SCHEMBL7054163 0.79 KIF11 (0.42) SMN1; SMN2POLBMEN1KMT2AALDH1A1
SCHEMBL10412017 0.79 HSD11B1 (0.44) ABCB1MEN1KMT2AHSD11B1MAPT
SCHEMBL5829016 0.79 TK1 (0.46) SMN1; SMN2POLBPPIDMEN1KMT2A
SCHEMBL8036817 0.78 SMN1; SMN2 (0.38) SMN1; SMN2POLBABCB1PPIDMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7795463-B2 Process for preparing diisopropyl((1-(hydroxymethyl)-cyclopropyl)oxy)methylphosphonate LG LIFE SCIENCES LTD. (KR) 2010-09-14 US claimed
JP-4422183-B2 2010-02-24 JP claimed
US-20090187019-A1 Process for preparing diisopropyl((1-(hydroxymethyl)-cyclopropyl)oxy)methylphosphonate LG LIFE SCIENCE LTD. (KR) 2009-07-23 US claimed
EP-1765838-A4 PROCESS FOR PREPARING DI-ISOPROPYL ((1(HYDROXYMETHYL)-CYCLOPROPYL)OXY) METHYLPHOSPHONATE LG LIFE SCIENCES LTD (KR) 2009-05-27 EP claimed
JP-2008505066-A 2008-02-21 JP claimed
EP-1765838-A1 PROCESS FOR PREPARING DI-ISOPROPYL ((1(HYDROXYMETHYL)-CYCLOPROPYL)OXY) METHYLPHOSPHONATE LG Life Sciences Ltd. (KR) 2007-03-28 EP claimed
WO-2006004330-A1 PROCESS FOR PREPARING DI-ISOPROPYL ((1(HYDROXYMETHYL)-CYCLOPROPYL)OXY) METHYLPHOSPHONATE LG LIFE SCIENCES LTD. (KR) 2006-01-12 WO claimed
EP-2760838-B1 DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS CHIESI FARM SPA (IT) 2017-05-10 EP disclosed
EP-2760838-B1 DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS CHIESI FARM SPA (IT) 2017-05-10 EP disclosed
US-9265768-B2 Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors CHIESI FARMACEUTICI S.P.A. (IT) 2016-02-23 US disclosed
EP-2760838-A1 DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS Chiesi Farmaceutici S.p.A. (IT) 2014-08-06 EP disclosed
US-20140142074-A1 DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS CHIESI FARMACEUTICI S.P.A. (IT) 2014-05-22 US disclosed
US-20140142074-A1 DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS CHIESI FARMACEUTICI S.P.A. (IT) 2014-05-22 US disclosed
US-7795463-B2 Process for preparing diisopropyl((1-(hydroxymethyl)-cyclopropyl)oxy)methylphosphonate LG LIFE SCIENCES LTD. (KR) 2010-09-14 US disclosed
US-20090187019-A1 Process for preparing diisopropyl((1-(hydroxymethyl)-cyclopropyl)oxy)methylphosphonate LG LIFE SCIENCE LTD. (KR) 2009-07-23 US disclosed
EP-1765838-A4 PROCESS FOR PREPARING DI-ISOPROPYL ((1(HYDROXYMETHYL)-CYCLOPROPYL)OXY) METHYLPHOSPHONATE LG LIFE SCIENCES LTD (KR) 2009-05-27 EP disclosed
EP-1765838-A1 PROCESS FOR PREPARING DI-ISOPROPYL ((1(HYDROXYMETHYL)-CYCLOPROPYL)OXY) METHYLPHOSPHONATE LG Life Sciences Ltd. (KR) 2007-03-28 EP disclosed
WO-2006004330-A1 PROCESS FOR PREPARING DI-ISOPROPYL ((1(HYDROXYMETHYL)-CYCLOPROPYL)OXY) METHYLPHOSPHONATE LG LIFE SCIENCES LTD. (KR) 2006-01-12 WO disclosed
US-5321000-A Benzhydryl compounds as herbicide antidotes MONSANTO COMPANY (US) 1994-06-14 US disclosed
US-4964893-A REDUCING INJURY TO A CROP PLANT MONSANTO COMPANY (US) 1990-10-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090187019-A1 Process for preparing diisopropyl((1-(hydroxymethyl)-cyclopropyl)oxy)methylphosphonate DHPS, ITPA, DCPS SMN1; SMN2 2074/4885POLB 88/4885ABCB1 530/4885
US-20140142074-A1 DERIVATIVES OF 1-PHENYL-2-PYRIDINYL ALKYL ALCOHOLS AS PHOSPHODIESTERASE INHIBITORS PDE4A, PDE4B, PDE3A SMN1; SMN2 2568/4885POLB 739/4885ABCB1 2125/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.