Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.45 |
| ▸ | CCR5 | P51681 | 1/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
| ▸ | NMT1 | P30419 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL785743 | 0.95 | SIGMAR1 (0.54) | SIGMAR1TSHRITGB3ITGA2BENPP2 | |
| Hydrochloric Acid SCHEMBL3947591 | 0.94 | SIGMAR1 (0.53) | SIGMAR1TSHRITGB3ITGA2BENPP2 | |
| SCHEMBL29418568 | 0.90 | SIGMAR1 (0.53) | SIGMAR1TSHRITGB3ITGA2BENPP2 | |
| SCHEMBL784819 | 0.90 | SIGMAR1 (0.53) | SIGMAR1TSHRITGB3ITGA2BENPP2 | |
| Hydrochloric Acid SCHEMBL1624880 | 0.89 | SIGMAR1 (0.52) | SIGMAR1TSHRITGB3ITGA2BENPP2 | |
| SCHEMBL8029227 | 0.88 | SIGMAR1 (0.64) | SIGMAR1TSHRENPP2CCR5TRPM8 | |
| Trifluoroacetic Acid SCHEMBL16718796 | 0.88 | ITGB3 (0.48) | SIGMAR1TSHRITGB3ITGA2BCCR5 | |
| SCHEMBL7762819 | 0.87 | SLC6A2 (0.52) | SIGMAR1TSHRITGB3ITGA2BCCR5 | |
| SCHEMBL10565202 | 0.87 | SLC6A2 (0.52) | SIGMAR1TSHRITGB3ITGA2BCCR5 | |
| SCHEMBL13738856 | 0.87 | SLC6A2 (0.52) | SIGMAR1TSHRITGB3ITGA2BCCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8680159-B2 | Bradykinin 1 receptor modulating compounds | GRUENENTHAL GMBH (DE) | 2014-03-25 | — | — | US | disclosed |
| US-8680159-B2 | Bradykinin 1 receptor modulating compounds | GRUENENTHAL GMBH (DE) | 2014-03-25 | — | — | US | disclosed |
| WO-2012038081-A1 | SUBSTITUTED BENZAMIDE COMPOUNDS | Grünenthal GmbH (DE) | 2012-03-29 | — | — | WO | disclosed |
| US-20120071461-A1 | Substituted Benzamide Compounds | GRUENENTHAL GMBH (DE) | 2012-03-22 | — | — | US | disclosed |
| US-20120071461-A1 | Substituted Benzamide Compounds | GRUENENTHAL GMBH (DE) | 2012-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120071461-A1 | Substituted Benzamide Compounds | BDKRB1, BDKRB2, HRH2 | SIGMAR1 369/4885TSHR 586/4885ITGB3 2555/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.