Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.58 |
| ▸ | FAAH | O00519 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 1/20 | 0.58 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.58 |
| ▸ | MTOR | P42345 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8037103 | 0.92 | MEN1 (0.65) | MAPK1FAAHCYP3A4CYP2D6TSHR | |
| SCHEMBL7572762 | 0.77 | SIGMAR1 (0.84) | CYP3A4CYP2D6SIGMAR1 | |
| Hydrochloric Acid SCHEMBL8032576 | 0.76 | SIGMAR1 (0.56) | SIGMAR1 | |
| Hydrochloric Acid SCHEMBL8021268 | 0.75 | FAAH (0.61) | FAAHSMN1; SMN2SIGMAR1 | |
| SCHEMBL9809319 | 0.74 | HRH1 (0.69) | MAPK1FAAHCYP3A4CYP2D6TSHR | |
| Hydrochloric Acid SCHEMBL10935509 | 0.74 | MEN1 (0.68) | MAPK1FAAHCYP3A4CYP2D6TSHR | |
| SCHEMBL10507988 | 0.74 | TSHR (0.67) | MAPK1FAAHCYP3A4CYP2D6TSHR | |
| Amperozide SCHEMBL17360644 | 0.74 | CYP3A4 (0.95) | MAPK1FAAHCYP3A4CYP2D6TSHR | |
| Hydrochloric Acid SCHEMBL8037098 | 0.74 | POLB (0.52) | TSHRMEN1BLMPMP22KMT2A | |
| SCHEMBL9809303 | 0.73 | MAPK1 (0.65) | MAPK1FAAHCYP3A4CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0620814-B1 | NOVEL PIPRAZINE CARBOXAMIDES | PHARMACIA & UPJOHN AB (SE) | 2000-03-22 | — | — | EP | disclosed |
| US-5574031-A | Piperazine carboxamides | PHARMACIA AKTIEBOLAG (SE) | 1996-11-12 | — | — | US | disclosed |