Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSB | P07858 | 5/20 | 0.42 |
| ▸ | CTSS | P25774 | 2/20 | 0.42 |
| ▸ | CTSK | P43235 | 2/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | GSR | P00390 | 1/20 | 0.42 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.36 |
| ▸ | CTSH | P09668 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL8039357 | 1.00 | CTSB (0.42) | CTSBCTSSCTSKCTSLGSR | |
| Lysine SCHEMBL8039122 | 0.89 | GSR (0.48) | GSRDPP9DPP8DPP7 | |
| Lysine SCHEMBL8037277 | 0.88 | GSR (0.43) | CTSBCTSSCTSKCTSLGSR | |
| Lysine SCHEMBL8037280 | 0.88 | GSR (0.43) | CTSBCTSSCTSKCTSLGSR | |
| Lysine SCHEMBL8037528 | 0.88 | GSR (0.44) | CTSBCTSSCTSKGSRDPP9 | |
| Lysine SCHEMBL8037527 | 0.88 | GSR (0.44) | CTSBCTSSCTSKGSRDPP9 | |
| Cyclohexylamine SCHEMBL8041254 | 0.88 | TP53 (0.41) | DPP9TP53ATMSLC1A5HTT | |
| Cyclohexylamine SCHEMBL8041252 | 0.88 | TP53 (0.41) | DPP9TP53ATMSLC1A5HTT | |
| Lysine SCHEMBL8037742 | 0.88 | ALDH1A1 (0.42) | GSRDPP9DPP8DPP7 | |
| 3-Formylbenzoic Acid SCHEMBL8039145 | 0.88 | UNG (0.48) | GSRDPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |