Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 4/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2E1 | P05181 | 3/20 | 0.35 |
| ▸ | CYP2C8 | P10632 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.35 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | NOS3 | P29474 | 3/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | SREBF2 | Q12772 | 2/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | GALR3 | O60755 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8916740 | 0.87 | TLR8 (0.40) | NOS2TLR8KDM4ECYP3A4MAPT | |
| SCHEMBL9189865 | 0.84 | NOS2 (0.39) | NOS2KDM4ECYP2E1CYP2C8CYP2D6 | |
| SCHEMBL17871070 | 0.81 | RECQL (0.33) | KDM4ELMNATSHRMAPT | |
| SCHEMBL6031149 | 0.80 | NOS2 (0.53) | NOS2TLR8KDM4ECYP3A4LMNA | |
| Hydrochloric Acid SCHEMBL22715609 | 0.76 | AOC3 (0.44) | — | |
| SCHEMBL3940135 | 0.76 | RECQL (0.39) | NOS2KDM4ECYP3A4LMNATSHR | |
| Hydrochloric Acid SCHEMBL29439707 | 0.76 | AOC3 (0.44) | — | |
| SCHEMBL8651131 | 0.76 | NOS3 (0.35) | NOS2NOS3NOS1 | |
| SCHEMBL25887068 | 0.74 | NOS2 (0.40) | NOS2TLR8KDM4ECYP3A4LMNA | |
| SCHEMBL21181779 | 0.73 | HRH4 (0.34) | NOS2TLR8KDM4ECYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0682655-B1 | METHOD FOR PREPARING 3-AMINO-2-CHLORO-4-ALKYLPYRIDINE OR -4-CYCLOALKYLPYRIDINES | BOEHRINGER INGELHEIM PHARMA (DE) | 2000-05-03 | — | — | EP | disclosed |
| US-5686618-A | Method for preparing 3-amino-2-chloro-4-alkylpyridine or-4-arylpyridine | BOEHRINGER INGELHEIM KG (DE) | 1997-11-11 | — | — | US | disclosed |
| EP-0682655-A1 | METHOD FOR PREPARING 3-AMINO-2-CHLORO-4-ALKYLPYRIDINE OR -4-ARYLPYRIDINE | BOEHRINGER INGELHEIM KG (DE) | 1995-11-22 | — | — | EP | disclosed |
| WO-1995015314-A1 | METHOD FOR PREPARING 3-AMINO-2-CHLORO-4-ALKYLPYRIDINE OR -4-ARYLPYRIDINE | BOEHRINGER INGELHEIM KG (DE) | 1995-06-08 | — | — | WO | disclosed |