Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 6/20 | 0.51 |
| ▸ | CHRNA6 | Q15825 | 3/20 | 0.51 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.46 |
| ▸ | CHRNA2 | Q15822 | 2/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.46 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | HTR3B | O95264 | 1/20 | 0.46 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.46 |
| ▸ | CHRNG | P07510 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8036171 | 0.84 | CHRNB2 (0.66) | CHRNB2CHRNA7CHRNA4CHRNA3 | |
| SCHEMBL13850676 | 0.82 | CYP2A6 (0.41) | CHRNB2CHRNA6CHRNA7CHRNA4CHRNA3 | |
| SCHEMBL7210361 | 0.79 | CYP11B2 (0.56) | CHRNB2CHRNA6CHRNA7CHRNA4CHRNA3 | |
| SCHEMBL7720464 | 0.79 | CYP11B2 (0.56) | CHRNB2CHRNA6CHRNA7CHRNA4CHRNA3 | |
| SCHEMBL8053285 | 0.77 | TSHR (0.44) | ALDH1A1MAPT | |
| SCHEMBL8045006 | 0.74 | SLC6A4 (0.47) | CHRNB2CHRNA6CHRNA4 | |
| SCHEMBL31406195 | 0.73 | SLC6A2 (0.68) | — | |
| SCHEMBL6489913 | 0.72 | OPRM1 (0.59) | CHRNB2CHRNA6CHRNA7CHRNA4CHRNA3 | |
| SCHEMBL6489917 | 0.72 | OPRM1 (0.59) | CHRNB2CHRNA6CHRNA7CHRNA4CHRNA3 | |
| SCHEMBL13681429 | 0.71 | CYP2A6 (0.53) | CHRNB2CHRNA6CHRNA7CHRNA4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090118326-A1 | Nicotinic Acetylcholine Receptor Modulators | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2009-05-07 | — | — | US | disclosed |
| WO-2009058120-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR MODULATORS | SRI INTERNATIONAL (US) | 2009-05-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118326-A1 | Nicotinic Acetylcholine Receptor Modulators | CHRNA10, CHRNA6, CHRNA5 | CHRNB2 12/4885CHRNA6 2/4885CHRNA7 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.