SCHEMBL8038799

SCHEMBL8038799

N#CCc1cccc2nnsc12

nearest known ligand 0.34

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.34
HPGD P15428 1/20 0.34
MEN1 O00255 1/20 0.34
MAPT P10636 1/20 0.34
KMT2A Q03164 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18905972 0.80 THRB (0.31)
SCHEMBL17468807 0.77 MAPT (0.39) ALDH1A1MEN1MAPTKMT2A
SCHEMBL543282 0.77 APOBEC3G (0.32) ALDH1A1MAPT
SCHEMBL3747880 0.73 PSMB8 (0.35) ALDH1A1
SCHEMBL9385271 0.67 EGLN1 (0.42) ALDH1A1MAPTKMT2A
SCHEMBL8049471 0.67 MAPT (0.33) ALDH1A1MAPT
SCHEMBL8051660 0.67 CYP1A2 (0.43) ALDH1A1MEN1MAPTKMT2A
SCHEMBL28993760 0.67 KMT2A (0.36) ALDH1A1HPGDMEN1MAPTKMT2A
SCHEMBL16533079 0.67 MAPT (0.47) ALDH1A1HPGDMEN1MAPTKMT2A
SCHEMBL29561649 0.66

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0502473-B1 Microbicidal benzo-1,2,3-thiadiazole derivatives NOVARTIS AG (CH) 2000-04-26 EP claimed
US-5384321-A Benzothiadiazole compounds CIBA-GEIGY CORPORATION (US) 1995-01-24 US claimed
US-5260423-A Fungicide, viricide or bactericide CIBA-GEIGY CORPORATION (US) 1993-11-09 US claimed
EP-0502473-A1 Microbicidal benzo-1,2,3-thiadiazole derivatives CIBA-GEIGY AG (CH) 1992-09-09 EP claimed
EP-0502473-B1 Microbicidal benzo-1,2,3-thiadiazole derivatives NOVARTIS AG (CH) 2000-04-26 EP disclosed
US-5384321-A Benzothiadiazole compounds CIBA-GEIGY CORPORATION (US) 1995-01-24 US disclosed
US-5260423-A Fungicide, viricide or bactericide CIBA-GEIGY CORPORATION (US) 1993-11-09 US disclosed
EP-0502473-A1 Microbicidal benzo-1,2,3-thiadiazole derivatives CIBA-GEIGY AG (CH) 1992-09-09 EP disclosed