Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 19/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2261477 | 1.00 | HTR4 (1.00) | HTR4ALDH1A1CYP3A4TSHRMAPK1 | |
| SCHEMBL12227452 | 1.00 | HTR4 (1.00) | HTR4ALDH1A1CYP3A4TSHRMAPK1 | |
| Trifluoroacetic Acid SCHEMBL2261833 | 0.94 | HTR4 (0.88) | HTR4 | |
| SCHEMBL8714839 | 0.90 | HTR4 (0.82) | HTR4CYP3A4 | |
| SCHEMBL8714841 | 0.90 | HTR4 (0.82) | HTR4CYP3A4 | |
| SCHEMBL16504004 | 0.85 | HTR4 (0.81) | HTR4ALDH1A1CYP3A4TSHRMAPK1 | |
| SCHEMBL2538722 | 0.85 | HTR4 (0.74) | HTR4 | |
| SCHEMBL7429870 | 0.84 | HTR4 (1.00) | HTR4 | |
| Hydrochloric Acid SCHEMBL3170515 | 0.83 | HTR4 (0.98) | HTR4 | |
| SCHEMBL7431308 | 0.82 | HTR4 (0.76) | HTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6117882-A | 5-HT4 agonists and antagonists | ELI LILLY AND COMPANY (US) | 2000-09-12 | — | — | US | disclosed |
| US-6069152-A | NERVOUS SYSTEM DISORDERS; CARDIOVASCULAR DISORDERS; GASTROINTESTINAL DISORDERS | ELI LILLY AND COMPANY (US) | 2000-05-30 | — | — | US | disclosed |
| EP-0908459-A1 | 5-HT4 Agonists and antagonists | ELI LILLY AND COMPANY (US) | 1999-04-14 | — | — | EP | disclosed |