Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 6/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GSR | P00390 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 2/20 | 0.36 |
| ▸ | HRH1 | P35367 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lysine SCHEMBL8039344 | 1.00 | ITGB3 (0.43) | ITGB3ITGA2BALDH1A1LMNAKDM4E | |
| Lysine SCHEMBL8035587 | 0.90 | ITGB3 (0.41) | ITGB3ITGA2BALDH1A1KDM4EGSR | |
| Lysine SCHEMBL8035591 | 0.90 | ITGB3 (0.41) | ITGB3ITGA2BALDH1A1KDM4EGSR | |
| Cyclohexylamine SCHEMBL8035658 | 0.89 | ALDH1A1 (0.41) | ITGB3ITGA2BALDH1A1LMNAKDM4E | |
| Cyclohexylamine SCHEMBL8035657 | 0.89 | ALDH1A1 (0.41) | ITGB3ITGA2BALDH1A1LMNAKDM4E | |
| Lysine SCHEMBL8035235 | 0.85 | DPP8 (0.45) | ITGB3ITGA2BALDH1A1GSRLTA4H | |
| Lysine SCHEMBL8035239 | 0.85 | DPP8 (0.45) | ITGB3ITGA2BALDH1A1GSRLTA4H | |
| Lysine SCHEMBL8035316 | 0.84 | GSR (0.46) | GSRDPP8 | |
| Lysine SCHEMBL8035311 | 0.84 | GSR (0.46) | GSRDPP8 | |
| Lysine SCHEMBL8039122 | 0.83 | GSR (0.48) | GSRDPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127381-A | A MELANOCORTIN RECEPTOR LIGAND FOR REGULATING FOOD INTAKE AND BODY WEIGHT, REGULATING CYTOKINE ACTIVITY, ANTI-INFLAMMATORY ACTIVITY | LION BIOSCIENCE AG (DE) | 2000-10-03 | — | — | US | disclosed |