Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.56 |
| ▸ | MAPKAPK2 | P49137 | 6/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 2/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8041738 | 0.82 | MAPKAPK2 (0.54) | SIRT1MAPKAPK2MAPTALDH1A1HTR2B | |
| SCHEMBL5612096 | 0.82 | PARP1 (0.41) | SIRT1MAPKAPK2MAPTTP53SMN1; SMN2 | |
| SCHEMBL30363250 | 0.81 | MAPKAPK2 (0.56) | SIRT1MAPKAPK2MAPTALDH1A1HTR2B | |
| SCHEMBL30363189 | 0.81 | MAPKAPK2 (0.56) | SIRT1MAPKAPK2MAPTALDH1A1HTR2B | |
| SCHEMBL6237350 | 0.81 | MAPKAPK2 (0.55) | SIRT1MAPKAPK2MAPTALDH1A1HTR2B | |
| SCHEMBL30363083 | 0.81 | MAPKAPK2 (0.55) | SIRT1MAPKAPK2MAPTALDH1A1HTR2B | |
| SCHEMBL30363161 | 0.81 | MAPKAPK2 (0.55) | SIRT1MAPKAPK2MAPTALDH1A1HTR2B | |
| SCHEMBL14363920 | 0.80 | MAPKAPK2 (0.54) | SIRT1MAPKAPK2MAPTALDH1A1HTR2B | |
| SCHEMBL17500277 | 0.80 | GRIN2B (0.59) | SIRT1MAPTALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL7501949 | 0.80 | SIGMAR1 (0.55) | SIRT1MAPKAPK2MAPTALDH1A1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6048868-A | CIRCADIAN RHYTHM DISORDERS; SLEEP DISORDERS; ANTIDEPRESSANTS | CEMAF (FR) | 2000-04-11 | — | — | US | claimed |
| US-6048868-A | CIRCADIAN RHYTHM DISORDERS; SLEEP DISORDERS; ANTIDEPRESSANTS | CEMAF (FR) | 2000-04-11 | — | — | US | disclosed |