Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPKAPK2 | P49137 | 6/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | TP53 | P04637 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8039623 | 0.82 | SIRT1 (0.56) | MAPKAPK2MAPTTP53ALDH1A1HTR2B | |
| SCHEMBL6353101 | 0.82 | TP53 (0.57) | MAPKAPK2MAPTTP53ALDH1A1ABCG2 | |
| SCHEMBL11250553 | 0.81 | ADRA1D (0.54) | MAPTSMN1; SMN2CYP1A1CYP1A2POLB | |
| SCHEMBL14363920 | 0.80 | MAPKAPK2 (0.54) | MAPKAPK2MAPTTP53ALDH1A1ABCG2 | |
| SCHEMBL6237350 | 0.79 | MAPKAPK2 (0.55) | MAPKAPK2MAPTTP53ALDH1A1ABCG2 | |
| SCHEMBL30363250 | 0.77 | MAPKAPK2 (0.56) | MAPKAPK2MAPTTP53ALDH1A1HTR2B | |
| SCHEMBL30363189 | 0.77 | MAPKAPK2 (0.56) | MAPKAPK2MAPTTP53ALDH1A1HTR2B | |
| SCHEMBL11366753 | 0.76 | MAPKAPK2 (0.55) | MAPKAPK2MAPTTP53ALDH1A1HTR2B | |
| SCHEMBL30363161 | 0.76 | MAPKAPK2 (0.55) | MAPKAPK2MAPTTP53ALDH1A1HTR2B | |
| SCHEMBL30363083 | 0.76 | MAPKAPK2 (0.55) | MAPKAPK2MAPTTP53ALDH1A1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6048868-A | CIRCADIAN RHYTHM DISORDERS; SLEEP DISORDERS; ANTIDEPRESSANTS | CEMAF (FR) | 2000-04-11 | — | — | US | disclosed |