Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB8 | P28062 | 2/20 | 0.67 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 4/20 | 0.39 |
| ▸ | GSK3B | P49841 | 4/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21063750 | 0.80 | PSMB8 (0.65) | PSMB8GSK3AGSK3BCCNB2CDK1 | |
| SCHEMBL8034068 | 0.77 | PSMB8 (0.49) | PSMB8GSK3AGSK3BCCNB2CDK1 | |
| SCHEMBL8022630 | 0.77 | PSMB8 (0.57) | PSMB8GSK3AGSK3BCCNB2CDK1 | |
| SCHEMBL24256511 | 0.76 | PSMB8 (0.59) | PSMB8GSK3AGSK3BCCNB2CDK1 | |
| SCHEMBL10574548 | 0.73 | PSMB8 (0.65) | PSMB8APPACHESOS2ALDH1A1 | |
| SCHEMBL1046142 | 0.72 | PSMB8 (0.43) | PSMB8GSK3AGSK3BCCNB2CDK1 | |
| SCHEMBL30938811 | 0.71 | PSMB8 (0.53) | PSMB8ALDH1A1KMT2AMAPTGAA | |
| SCHEMBL492446 | 0.71 | PSMB8 (0.53) | PSMB8ALDH1A1KMT2AMAPTGAA | |
| SCHEMBL9305472 | 0.71 | APP (0.46) | PSMB8APPACHEALDH1A1KMT2A | |
| SCHEMBL9305900 | 0.71 | APP (0.46) | PSMB8APPACHEALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6130217-A | ANTITUMOR | PFIZER INC (US) | 2000-10-10 | — | — | US | disclosed |
| WO-1994022846-A1 | COMPOUNDS ENHANCING ANTITUMOR ACTIVITY OF OTHER CYTOTOXIC AGENTS | PFIZER INC. (US) | 1994-10-13 | — | — | WO | disclosed |