SCHEMBL492446

SCHEMBL492446

N#Cc1nc2ccccc2s1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PSMB8 P28062 3/20 0.53
IDO1 P14902 1/20 0.50
THRB P10828 1/20 0.50
RECQL P46063 1/20 0.50
ALDH1A1 P00352 6/20 0.48
HPGD P15428 2/20 0.48
HSD17B10 Q99714 2/20 0.48
ADRA2A P08913 1/20 0.48
FBP1 P09467 1/20 0.48
ADORA3 P0DMS8 1/20 0.48
DRD2 P14416 1/20 0.48
ALOX15 P16050 1/20 0.48
ADRA2B P18089 1/20 0.48
ADRA2C P18825 1/20 0.48
DRD1 P21728 1/20 0.48
MC5R P33032 1/20 0.48
OPRM1 P35372 1/20 0.48
DRD3 P35462 1/20 0.48
OPRK1 P41145 1/20 0.48
CCR2 P41597 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30938811 1.00 PSMB8 (0.53) PSMB8IDO1THRBRECQLALDH1A1
SCHEMBL15874315 0.79 IDO1 (0.50) PSMB8IDO1THRBRECQLALDH1A1
SCHEMBL29800442 0.79 IDO1 (0.50) PSMB8IDO1THRBRECQLALDH1A1
SCHEMBL221981 0.79 ALDH1A1 (0.51) PSMB8IDO1ALDH1A1HPGDHSD17B10
SCHEMBL5092877 0.79 IDO1 (0.50) PSMB8IDO1THRBRECQLALDH1A1
SCHEMBL3096380 0.79 IDO1 (0.50) PSMB8IDO1THRBRECQLALDH1A1
SCHEMBL719079 0.79 IDO1 (0.50) PSMB8IDO1THRBRECQLALDH1A1
SCHEMBL1436096 0.78 IDO1 (0.48) PSMB8IDO1THRBRECQLALDH1A1
SCHEMBL9796864 0.76 PSMB8 (0.44) PSMB8ALDH1A1HPGDHSD17B10NPC1
SCHEMBL14742828 0.75 PSMB8 (0.41) PSMB8DYRK1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 936 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122060052-A Method for chemically modifying nano antibody by site specificity and application thereof 哈尔滨工业大学 2026-05-19 CN claimed
EP-3617235-B1 COMPOUND HAVING SUBSTANCE THAT HAS AFFINITY FOR SOLUBLE PROTEIN, CLEAVABLE MOIETY, AND REACTIVE GROUP, OR SALT THEREOF AJINOMOTO KK (JP) 2026-02-18 EP claimed
EP-4692104-A1 CONJUGATE OF ANTIBODY AND FUNCTIONAL SUBSTANCE OR SALT OF SAID CONJUGATE, AND ANTIBODY INTERMEDIATE HAVING THIOL GROUP OR SALT OF SAID ANTIBODY INTERMEDIATE AJINOMOTO CO., INC. (JP) 2026-02-11 EP claimed
US-20250312265-A1 CROSSLINKED MATERIALS FOUNT BIO, INC. 2025-10-09 US claimed
US-20250270622-A1 NUCLEIC ACID ASSAYS USING CLICK CHEMISTRY BIOCONJUGATION 10X GENOMICS, INC. (US) 2025-08-28 US claimed
US-12311048-B2 Crosslinked materials FOUNT BIO, INC. (US) 2025-05-27 US claimed
CN-119823371-A Conjugate of indocyanine green and multi-arm polyethylene glycol or pharmaceutically acceptable salt thereof, and preparation method and application thereof 南京市云影生物科技有限公司 2025-04-15 CN claimed
CN-115728495-B Charge-mediated micro-channel current biosensing method based on directional coupling technology and application thereof 华中农业大学 2025-02-25 CN claimed
US-12209273-B2 Nucleic acid assays using click chemistry bioconjugation 10X GENOMICS, INC. (US) 2025-01-28 US claimed
WO-2024210178-A1 CONJUGATE OF ANTIBODY AND FUNCTIONAL SUBSTANCE OR SALT OF SAID CONJUGATE, AND ANTIBODY INTERMEDIATE HAVING THIOL GROUP OR SALT OF SAID ANTIBODY INTERMEDIATE 味の素株式会社 2024-10-10 WO claimed
CN-101874044-A Polymers functionalized with heterocyclic nitrile compounds BRIDGESTONE CORP 2010-10-27 CN claimed
EP-2203482-A1 POLYMERS FUNCTIONALIZED WITH HETEROCYCLIC NITRILE COMPOUNDS Bridgestone Corporation (JP) 2010-07-07 EP claimed
WO-2009051702-A1 POLYMERS FUNCTIONALIZED WITH HETEROCYCLIC NITRILE COMPOUNDS BRIDGESTONE CORPORATION (JP) 2009-04-23 WO claimed
WO-2009051700-A1 POLYMERS FUNCTIONALIZED WITH HETEROCYCLIC NITRILE COMPOUNDS BRIDGESTONE CORPORATION (US) 2009-04-23 WO claimed
US-20090099325-A1 POLYMERS FUNCTIONALIZED WITH HETEROCYCLIC NITRILE COMPOUNDS BRIDGESTONE CORPORATION 2009-04-16 US claimed
US-20070197510-A1 Nitriles and medicinal compositions containing the same as the active ingredient ONO PHARMACEUTICAL CO., LTD. (JP) 2007-08-23 US claimed
EP-1724264-A1 NITRILES AND MEDICINAL COMPOSITIONS CONTAINING THE SAME AS THE ACTIVE INGREDIENT ONO PHARMACEUTICAL CO., LTD. (JP) 2006-11-22 EP claimed
EP-0599906-B1 HERBICIDES CONTAINING 3-AMINOBENZO B]THIOPHENES AS AN ANTIDOTE BASF AG (DE) 1997-01-15 EP claimed
EP-0599906-A1 HERBICIDES CONTAINING 3-AMINOBENZO B]THIOPHENES AS AN ANTIDOTE. BASF AG (DE) 1994-06-08 EP claimed
WO-1993004057-A2 HERBICIDES CONTAINING 3-AMINOBENZO[B]THIOPHENES AS AN ANTIDOTE BASF AKTIENGESELLSCHAFT (DE) 1993-03-04 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070197510-A1 Nitriles and medicinal compositions containing the same as the active ingredient CTRL, NOS1, CPN1 PSMB8 441/4885IDO1 1167/4885THRB 3446/4885
US-12311048-B2 Crosslinked materials DCLRE1A, COL2A1, MTCL3 PSMB8 2813/4885IDO1 4707/4885THRB 4878/4885
US-20250312265-A1 CROSSLINKED MATERIALS DCLRE1A, MTCL3, COL2A1 PSMB8 2469/4885IDO1 4667/4885THRB 4879/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.