Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 3/20 | 0.54 |
| ▸ | ACAT1 | P24752 | 2/20 | 0.54 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 2/20 | 0.36 |
| ▸ | PLK1 | P53350 | 4/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.32 |
| ▸ | PDK3 | Q15120 | 3/20 | 0.32 |
| ▸ | PDK4 | Q16654 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.31 |
| ▸ | PLA2G5 | P39877 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8080878 | 0.87 | SOAT2 (0.48) | SOAT1ACAT1SOAT2ESR1PLK1 | |
| SCHEMBL8071721 | 0.85 | SOAT2 (0.46) | SOAT1ACAT1SOAT2ESR1THRB | |
| Eflucimibe SCHEMBL8041449 | 0.85 | SOAT2 (0.82) | SOAT1ACAT1SOAT2PLK1ALDH1A1 | |
| SCHEMBL13193304 | 0.84 | SOAT2 (0.52) | SOAT1ACAT1SOAT2 | |
| SCHEMBL8071717 | 0.84 | SOAT2 (0.52) | SOAT1ACAT1SOAT2PLK1 | |
| SCHEMBL9446276 | 0.81 | SOAT1 (0.49) | SOAT1ACAT1SOAT2ESR1PDK1 | |
| SCHEMBL9446344 | 0.81 | SOAT1 (0.49) | SOAT1ACAT1SOAT2ESR1PDK1 | |
| SCHEMBL9446308 | 0.81 | SOAT1 (0.49) | SOAT1ACAT1SOAT2ESR1PDK1 | |
| SCHEMBL9446314 | 0.81 | SOAT1 (0.49) | SOAT1ACAT1SOAT2ESR1PDK1 | |
| SCHEMBL9446319 | 0.81 | SOAT1 (0.49) | SOAT1ACAT1SOAT2ESR1PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874812-B1 | NOVEL 2,3,5-TRIMETHYL-4-HYDROXY ANILIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTICAL USE THEREOF | PF MEDICAMENT (FR) | 2000-04-05 | — | — | EP | disclosed |
| US-5990173-A | ANTICHOLESTEROL AGENTS; TREATING ATHEROSCLEROSIS; ENZYME INHIBITORS OF ACYLCOENZYME A:CHOLESTEROL ACYLTRANSFERASE (ACAT) | PIERRE FABRE MEDICAMENT (FR) | 1999-11-23 | — | — | US | disclosed |