Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 16/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043544 | 0.86 | HIF1A (0.46) | HIF1AKDM4ELMNASMN1; SMN2HTT | |
| SCHEMBL8043618 | 0.84 | SMN1; SMN2 (0.51) | HIF1AKDM4ELMNASMN1; SMN2HTT | |
| SCHEMBL8041606 | 0.79 | HIF1A (0.51) | HIF1AKDM4ELMNASMN1; SMN2HTT | |
| SCHEMBL8043531 | 0.79 | METAP1 (0.49) | HIF1AKDM4ELMNASMN1; SMN2HTT | |
| SCHEMBL8042397 | 0.79 | HIF1A (0.79) | HIF1AKDM4ELMNASMN1; SMN2HTT | |
| SCHEMBL8042357 | 0.78 | HIF1A (0.80) | HIF1AKDM4ELMNASMN1; SMN2HTT | |
| SCHEMBL8045550 | 0.78 | HIF1A (0.58) | HIF1AKDM4ELMNASMN1; SMN2HTT | |
| SCHEMBL8042355 | 0.76 | HIF1A (0.47) | HIF1AKDM4ELMNASMN1; SMN2HTT | |
| SCHEMBL8043537 | 0.76 | HIF1A (0.77) | HIF1AKDM4ELMNASMN1; SMN2HTT | |
| SCHEMBL8043602 | 0.75 | GRM5 (0.54) | HIF1AKDM4ELMNASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6159974-A | LDL receptor gene expression promoters | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | claimed |
| US-6159974-A | LDL receptor gene expression promoters | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | disclosed |