Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 13/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043618 | 0.88 | SMN1; SMN2 (0.51) | HIF1AKDM4ELMNASMN1; SMN2HTT | |
| SCHEMBL8041599 | 0.86 | HIF1A (0.48) | HIF1AKDM4ELMNASMN1; SMN2HTT | |
| SCHEMBL8032107 | 0.81 | HIF1A (0.45) | HIF1AKDM4ELMNASMN1; SMN2HTT | |
| SCHEMBL8041622 | 0.79 | HIF1A (0.58) | HIF1AKDM4ELMNASMN1; SMN2HTT | |
| SCHEMBL8049599 | 0.77 | CYP1A2 (0.57) | KDM4ELMNASMN1; SMN2TRPV1 | |
| SCHEMBL8049612 | 0.76 | HIF1A (0.61) | HIF1AKDM4ELMNASMN1; SMN2HTT | |
| SCHEMBL8043588 | 0.76 | HIF1A (0.43) | HIF1AKDM4ELMNASMN1; SMN2HTT | |
| SCHEMBL30151316 | 0.76 | GAA (0.50) | KDM4ESMN1; SMN2PPP1CAKMT2AS1PR1 | |
| SCHEMBL8042368 | 0.76 | HIF1A (0.50) | HIF1AKDM4ELMNASMN1; SMN2HTT | |
| SCHEMBL8043550 | 0.75 | CYP1A2 (0.49) | HIF1AKDM4ELMNASMN1; SMN2MITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6159974-A | LDL receptor gene expression promoters | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | claimed |
| US-6159974-A | LDL receptor gene expression promoters | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 2000-12-12 | — | — | US | disclosed |