Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 4/20 | 0.36 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | LOX | P28300 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8048119 | 0.93 | MAPK8 (0.38) | MAPK8MAPK9LOXL2ALDH1A1MAPK10 | |
| SCHEMBL8043817 | 0.88 | MAPK8 (0.37) | MAPK8MAPK9LOXL2ALDH1A1MAPK10 | |
| SCHEMBL8044752 | 0.87 | MAPK8 (0.33) | MAPK8MAPK9LOXL2MAPK10LOX | |
| SCHEMBL8042354 | 0.84 | MAPK8 (0.34) | MAPK8MAPK9LOXL2MAPK10LOX | |
| SCHEMBL8043608 | 0.84 | APEX1 (0.33) | MAPK8MAPK9ALDH1A1 | |
| SCHEMBL8043963 | 0.83 | ATM (0.42) | ALDH1A1NPC1RAB9A | |
| SCHEMBL8044039 | 0.82 | ALDH1A1 (0.37) | MAPK8MAPK9LOXL2ALDH1A1TSHR | |
| SCHEMBL8051075 | 0.81 | ALDH1A1 (0.35) | ALDH1A1NPC1 | |
| SCHEMBL8043583 | 0.81 | AKT1 (0.33) | MAPK8MAPK9LOXL2MAPK10LOX | |
| SCHEMBL8043647 | 0.80 | F2 (0.40) | MAPK8MAPK9LOXL2ALDH1A1MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |