Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.31 |
| ▸ | GLS | O94925 | 1/20 | 0.31 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043583 | 0.88 | AKT1 (0.33) | MAPK8MAPK9FFAR2 | |
| SCHEMBL8044752 | 0.86 | MAPK8 (0.33) | MAPK8MAPK9GLSFFAR2 | |
| SCHEMBL8051075 | 0.85 | ALDH1A1 (0.35) | ALDH1A1 | |
| SCHEMBL8048119 | 0.85 | MAPK8 (0.38) | ALDH1A1MAPK8MAPK9 | |
| SCHEMBL8041884 | 0.84 | MAPK8 (0.36) | ALDH1A1MAPK8MAPK9 | |
| SCHEMBL8042354 | 0.83 | MAPK8 (0.34) | MAPK8MAPK9FFAR2 | |
| SCHEMBL8043963 | 0.82 | ATM (0.42) | ALDH1A1 | |
| SCHEMBL8043817 | 0.82 | MAPK8 (0.37) | ALDH1A1MAPK8MAPK9 | |
| SCHEMBL8043647 | 0.81 | F2 (0.40) | ALDH1A1MAPK8MAPK9FFAR2 | |
| SCHEMBL8043212 | 0.80 | RXRA (0.39) | APEX1HDAC6ALDH1A1FFAR1MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |