Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | EP300 | Q09472 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8048309 | 0.88 | ALDH1A1 (0.52) | HPGDEP300KMT2AMEN1ALDH1A1 | |
| SCHEMBL8050190 | 0.86 | ALDH1A1 (0.40) | HPGDKMT2AALDH1A1MAPK1NPSR1 | |
| SCHEMBL8033930 | 0.85 | ALDH1A1 (0.39) | HPGDKMT2AALDH1A1MAPK1NPSR1 | |
| SCHEMBL8712725 | 0.85 | PTGS2 (0.39) | RECQLKMT2AALDH1A1MAPK1HTT | |
| SCHEMBL8042987 | 0.84 | PTGS2 (0.50) | HPGDKMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL8042407 | 0.84 | PTGS2 (0.43) | HPGDKMT2AALDH1A1MAPK1HTT | |
| SCHEMBL8042077 | 0.84 | ALDH1A1 (0.39) | HPGDKMT2AALDH1A1MAPK1NPSR1 | |
| SCHEMBL8046366 | 0.84 | PTGS2 (0.50) | RECQLHPGDKMT2AMEN1ALDH1A1 | |
| SCHEMBL8041809 | 0.83 | SMN1; SMN2 (0.44) | HPGDKMT2AMEN1ALDH1A1MAPK1 | |
| SCHEMBL8045818 | 0.83 | HPGD (0.51) | RECQLHPGDEP300KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |