Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PRNP | P04156 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8033699 | 0.85 | KMT2A (0.55) | TP53TSHRKMT2ACYP3A4CYP2C19 | |
| SCHEMBL8045447 | 0.83 | POLA1 (0.41) | TP53TSHRKMT2ACYP3A4MEN1 | |
| SCHEMBL8044154 | 0.80 | SMN1; SMN2 (0.43) | TSHRMAPTLMNANPC1ALDH1A1 | |
| SCHEMBL8044158 | 0.80 | TSHR (0.54) | TSHRKMT2ACYP3A4CYP2C19MEN1 | |
| SCHEMBL8046872 | 0.80 | RPA1 (0.52) | TP53TSHRKMT2AMEN1MAPT | |
| SCHEMBL8042069 | 0.80 | LMNA (0.40) | TP53TSHRKMT2AMEN1MAPT | |
| SCHEMBL8044821 | 0.79 | ALDH1A1 (0.47) | TP53TSHRKMT2ACYP3A4CYP2C19 | |
| SCHEMBL8050159 | 0.79 | LMNA (0.42) | TP53TSHRKMT2AMEN1MAPT | |
| SCHEMBL8047465 | 0.77 | NPSR1 (0.47) | TP53TSHRKMT2AMEN1MAPT | |
| SCHEMBL8716255 | 0.77 | TP53 (0.43) | TP53TSHRKMT2ACYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |