Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5108619 | 0.86 | CHRNB2 (0.42) | CHRNB2CHRNA4CHRM2CHRM4CHRM5 | |
| SCHEMBL31730952 | 0.83 | TLR8 (0.43) | CHRNB2CHRNA4CHRM2CHRM4CHRM5 | |
| SCHEMBL4862795 | 0.79 | CHRNB2 (0.42) | CHRNB2CHRNA4CHRM2CHRM4CHRM5 | |
| SCHEMBL12152177 | 0.79 | CHRNB2 (0.42) | CHRNB2CHRNA4CHRM2CHRM4CHRM5 | |
| SCHEMBL9043521 | 0.79 | CHRNB2 (0.42) | CHRNB2CHRNA4CHRM2CHRM4CHRM5 | |
| SCHEMBL4723565 | 0.72 | CHRNB2 (0.49) | CHRNB2CHRNA4CHRM2CHRM4CHRM5 | |
| SCHEMBL28428414 | 0.71 | CHRM2 (0.55) | CHRNB2CHRNA4CHRM2CHRM4CHRM5 | |
| SCHEMBL8035996 | 0.71 | KDM4E (0.36) | NPC1RAB9AMAPTALDH1A1KDM4E | |
| SCHEMBL2249038 | 0.71 | LOXL2 (0.60) | RAB9AALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL24776544 | 0.70 | CHRM2 (0.38) | CHRNB2CHRNA4CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000076990-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2000-12-21 | — | — | WO | disclosed |