Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 13/20 | 0.37 |
| ▸ | LMNA | P02545 | 7/20 | 0.37 |
| ▸ | HTT | P42858 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | TP53 | P04637 | 4/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 5/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043087 | 0.87 | ALDH1A1 (0.36) | ALDH1A1LMNAHTTSMN1; SMN2KMT2A | |
| SCHEMBL8047340 | 0.83 | ALDH1A1 (0.40) | ALDH1A1LMNAHTTSMN1; SMN2KMT2A | |
| SCHEMBL8047853 | 0.82 | KMT2A (0.40) | ALDH1A1LMNAHTTSMN1; SMN2KMT2A | |
| SCHEMBL8043601 | 0.82 | ALDH1A1 (0.37) | ALDH1A1LMNAHTTSMN1; SMN2KMT2A | |
| SCHEMBL8043194 | 0.81 | KMT2A (0.43) | ALDH1A1LMNAHTTSMN1; SMN2KMT2A | |
| SCHEMBL8034063 | 0.81 | ALDH1A1 (0.36) | ALDH1A1LMNAHTTSMN1; SMN2KMT2A | |
| SCHEMBL8044269 | 0.81 | ALDH1A1 (0.34) | ALDH1A1LMNAHTTSMN1; SMN2KMT2A | |
| SCHEMBL8048414 | 0.81 | LMNA (0.36) | ALDH1A1LMNAHTTSMN1; SMN2KMT2A | |
| SCHEMBL8045769 | 0.80 | ALDH1A1 (0.36) | ALDH1A1LMNAHTTSMN1; SMN2KMT2A | |
| SCHEMBL8043945 | 0.78 | ALDH1A1 (0.57) | ALDH1A1LMNAHTTSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |