Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 3/20 | 0.61 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.61 |
| ▸ | DRD2 | P14416 | 12/20 | 0.61 |
| ▸ | DRD3 | P35462 | 12/20 | 0.61 |
| ▸ | DRD4 | P21917 | 11/20 | 0.61 |
| ▸ | CHRM2 | P08172 | 11/20 | 0.61 |
| ▸ | CHRM4 | P08173 | 11/20 | 0.61 |
| ▸ | CHRM5 | P08912 | 11/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 11/20 | 0.61 |
| ▸ | CHRM3 | P20309 | 11/20 | 0.61 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.55 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.55 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.55 |
| ▸ | HTR7 | P34969 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042443 | 1.00 | GRIN1 (0.61) | GRIN1GRIN2BDRD2DRD3DRD4 | |
| Hydrochloric Acid SCHEMBL8045702 | 0.99 | GRIN1 (0.60) | GRIN1GRIN2BDRD2DRD3DRD4 | |
| Hydrochloric Acid SCHEMBL8045698 | 0.99 | GRIN1 (0.60) | GRIN1GRIN2BDRD2DRD3DRD4 | |
| SCHEMBL8042469 | 0.84 | DRD2 (0.64) | DRD2CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL8042466 | 0.84 | DRD2 (0.64) | DRD2CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL8042425 | 0.81 | DRD2 (0.63) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| SCHEMBL8042421 | 0.81 | DRD2 (0.63) | DRD2DRD3ADRA1DADRA1AADRA1B | |
| SCHEMBL8045751 | 0.77 | DRD2 (0.61) | DRD2DRD4CHRM2CHRM4CHRM5 | |
| SCHEMBL8043711 | 0.77 | DRD2 (0.61) | DRD2DRD4CHRM2CHRM4CHRM5 | |
| SCHEMBL8043716 | 0.77 | DRD2 (0.61) | DRD2DRD4CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6133275-A | ALPHA 1 ADRENORECEPTOR ANTAGONISTS; TREATING BENIGN PROSTATIC HYPERPLASIA AND OTHER UROLOGICAL DISEASES E.G., BLADDER OUTLET OBSTRUCTION), NEUROGENIC BLADDER AND GYNECOLOGICAL SYNDROMES, E.G., DYSMENORRHEA; UTERINE MUSCLE RELAXANTS | ABBOTT LABORATORIES (US) | 2000-10-17 | — | — | US | disclosed |