Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.64 |
| ▸ | HTR2A | P28223 | 3/20 | 0.64 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.64 |
| ▸ | CHRM1 | P11229 | 14/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.50 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 1/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.50 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8042466 | 1.00 | DRD2 (0.64) | DRD2HTR2AMCHR1CHRM1KCNH2 | |
| SCHEMBL8042446 | 0.84 | GRIN1 (0.61) | DRD2CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL8042443 | 0.84 | GRIN1 (0.61) | DRD2CHRM1CHRM2CHRM4CHRM5 | |
| Hydrochloric Acid SCHEMBL8045702 | 0.83 | GRIN1 (0.60) | DRD2CHRM1CHRM2CHRM4CHRM5 | |
| Hydrochloric Acid SCHEMBL8045698 | 0.83 | GRIN1 (0.60) | DRD2CHRM1CHRM2CHRM4CHRM5 | |
| SCHEMBL8042421 | 0.79 | DRD2 (0.63) | DRD2ADRA1AHRH1ADRA1B | |
| SCHEMBL8042425 | 0.79 | DRD2 (0.63) | DRD2ADRA1AHRH1ADRA1B | |
| SCHEMBL4429177 | 0.75 | UTS2R (0.57) | DRD2HTR2AMCHR1CHRM1KCNH2 | |
| SCHEMBL8013233 | 0.75 | CHRM1 (0.61) | DRD2HTR2AMCHR1CHRM1KCNH2 | |
| SCHEMBL8045751 | 0.75 | DRD2 (0.61) | DRD2CHRM1CHRM2CHRM4CHRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6133275-A | ALPHA 1 ADRENORECEPTOR ANTAGONISTS; TREATING BENIGN PROSTATIC HYPERPLASIA AND OTHER UROLOGICAL DISEASES E.G., BLADDER OUTLET OBSTRUCTION), NEUROGENIC BLADDER AND GYNECOLOGICAL SYNDROMES, E.G., DYSMENORRHEA; UTERINE MUSCLE RELAXANTS | ABBOTT LABORATORIES (US) | 2000-10-17 | — | — | US | disclosed |
| WO-1999057122-A1 | 3-PHENYLPYRROLE ALPHA-1 ADRENERGIC COMPOUNDS | ABBOTT LABORATORIES (US) | 1999-11-11 | — | — | WO | disclosed |