Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | MIF | P14174 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALPG | P10696 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8034049 | 0.85 | TSHR (0.58) | CYP3A4KDM4ETSHRALDH1A1NPSR1 | |
| SCHEMBL8041830 | 0.83 | CPB1 (0.47) | CYP3A4KDM4ENPC1RAB9ATSHR | |
| SCHEMBL8045746 | 0.83 | KMT2A (0.53) | HDAC6CYP3A4KDM4ENPC1RAB9A | |
| SCHEMBL8046882 | 0.83 | RECQL (0.41) | HDAC6CYP3A4KDM4ENPC1RAB9A | |
| SCHEMBL8042001 | 0.82 | HSD17B10 (0.50) | HDAC6CYP3A4KDM4ETSHRALDH1A1 | |
| SCHEMBL8041833 | 0.82 | ALDH1A1 (0.46) | CYP3A4KDM4ENPC1RAB9ATSHR | |
| SCHEMBL8048062 | 0.81 | KDM4E (0.58) | HDAC6CYP3A4KDM4ENPC1RAB9A | |
| SCHEMBL8050851 | 0.81 | TSHR (0.49) | HDAC6CYP3A4KDM4ETSHRALDH1A1 | |
| SCHEMBL8050243 | 0.81 | NPSR1 (0.57) | CYP3A4KDM4ETSHRALDH1A1NPSR1 | |
| SCHEMBL8043876 | 0.81 | RECQL (0.50) | CYP3A4KDM4ENPC1RAB9ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |