Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ALPG | P10696 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | MIF | P14174 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8050857 | 0.87 | HSD17B10 (0.48) | HDAC6CYP3A4MAPTALDH1A1HSD17B10 | |
| SCHEMBL8042984 | 0.87 | TSHR (0.50) | CYP3A4MAPTALDH1A1HSD17B10USP2 | |
| SCHEMBL8048043 | 0.85 | CPB1 (0.43) | HDAC6CYP3A4NPC1RAB9AMAPT | |
| SCHEMBL8034281 | 0.85 | KMT2A (0.40) | HDAC6CYP3A4NPC1RAB9AMAPT | |
| SCHEMBL8041892 | 0.85 | MEN1 (0.49) | HDAC6CYP3A4NPC1RAB9AMAPT | |
| SCHEMBL8048048 | 0.84 | HSD17B10 (0.43) | CYP3A4NPC1RAB9AMAPTGAA | |
| SCHEMBL8043248 | 0.83 | HSD17B10 (0.44) | HDAC6CYP3A4ALDH1A1HSD17B10USP2 | |
| SCHEMBL8033879 | 0.83 | SMN1; SMN2 (0.45) | NPC1RAB9AMAPTPOLBGAA | |
| SCHEMBL8034389 | 0.83 | RECQL (0.46) | HDAC6CYP3A4NPC1RAB9AMAPT | |
| SCHEMBL8048014 | 0.83 | HSD17B10 (0.57) | CYP3A4NPC1RAB9AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |