Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALPG | P10696 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | RCE1 | Q9Y256 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8041892 | 0.88 | MEN1 (0.49) | KMT2AMEN1MAPTRAB9ACYP3A4 | |
| SCHEMBL8033172 | 0.86 | MAPT (0.38) | KMT2AMEN1MAPTRAB9ACYP3A4 | |
| SCHEMBL8048043 | 0.85 | CPB1 (0.43) | KMT2AMEN1MAPTRAB9ACYP3A4 | |
| SCHEMBL8044738 | 0.85 | CSNK1D (0.39) | KMT2AMEN1MAPTRAB9ANPC1 | |
| SCHEMBL8043400 | 0.85 | ALDH1A1 (0.53) | KMT2AMEN1MAPTRAB9ACYP3A4 | |
| SCHEMBL8042533 | 0.85 | HDAC6 (0.53) | KMT2AMAPTRAB9ACYP3A4NPC1 | |
| SCHEMBL8043389 | 0.84 | PDK1 (0.44) | KMT2AMEN1MAPTRAB9ACYP3A4 | |
| SCHEMBL8034389 | 0.80 | RECQL (0.46) | KMT2AMEN1MAPTRAB9ACYP3A4 | |
| SCHEMBL8050857 | 0.80 | HSD17B10 (0.48) | KMT2AMEN1MAPTCYP3A4CYP1A2 | |
| SCHEMBL8042984 | 0.80 | TSHR (0.50) | KMT2AMEN1MAPTCYP3A4CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |