Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.45 |
| ▸ | RELA | Q04206 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | MITF | O75030 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8044777 | 0.85 | NFKB1 (0.43) | SMN1; SMN2NFKB1NFKB2RELAKDM4E | |
| SCHEMBL8042533 | 0.83 | HDAC6 (0.53) | SMN1; SMN2NFKB1NFKB2RELAKDM4E | |
| SCHEMBL8032955 | 0.81 | ALDH1A1 (0.49) | SMN1; SMN2NFKB1NFKB2RELAKDM4E | |
| SCHEMBL8043375 | 0.81 | SMN1; SMN2 (0.45) | SMN1; SMN2NFKB1NFKB2RELAKDM4E | |
| SCHEMBL8044591 | 0.79 | PKM (0.46) | SMN1; SMN2KDM4ELMNANPC1RAB9A | |
| SCHEMBL8050070 | 0.79 | NFKB1 (0.45) | SMN1; SMN2NFKB1NFKB2RELAKDM4E | |
| SCHEMBL8044191 | 0.78 | PDK1 (0.60) | SMN1; SMN2LMNANPC1RAB9ATDP1 | |
| SCHEMBL8044712 | 0.78 | NPC1 (0.49) | SMN1; SMN2NFKB1NFKB2RELAKDM4E | |
| SCHEMBL8042817 | 0.77 | ALDH1A1 (0.50) | SMN1; SMN2KDM4ELMNANPC1RAB9A | |
| SCHEMBL8042101 | 0.77 | HPGD (0.45) | SMN1; SMN2NFKB1NFKB2RELAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |