Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Retinol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.91 |
| ▸ | MAPT | P10636 | 7/20 | 0.91 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.91 |
| ▸ | APP | P05067 | 4/20 | 0.91 |
| ▸ | SNCA | P37840 | 4/20 | 0.91 |
| ▸ | RBP4 | P02753 | 4/20 | 0.91 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.91 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.91 |
| ▸ | MEN1 | O00255 | 2/20 | 0.91 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.91 |
| ▸ | TSHR | P16473 | 2/20 | 0.91 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.91 |
| ▸ | USP2 | O75604 | 1/20 | 0.91 |
| ▸ | RXRA | P19793 | 5/20 | 0.74 |
| ▸ | RARA | P10276 | 4/20 | 0.74 |
| ▸ | RARB | P10826 | 4/20 | 0.74 |
| ▸ | RARG | P13631 | 4/20 | 0.74 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.74 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Retinol SCHEMBL21270044 | 1.00 | ALDH1A1 (0.91) | ALDH1A1MAPTCYP3A4APPSNCA | |
| Retinol SCHEMBL7507482 | 0.98 | ALDH1A1 (0.91) | ALDH1A1MAPTCYP3A4APPSNCA | |
| Retinol SCHEMBL27687647 | 0.95 | ALDH1A1 (0.87) | ALDH1A1MAPTCYP3A4APPSNCA | |
| Retinol SCHEMBL27566389 | 0.95 | ALDH1A1 (0.87) | ALDH1A1MAPTCYP3A4APPSNCA | |
| Retinol SCHEMBL3113 | 0.95 | ALDH1A1 (1.00) | ALDH1A1MAPTCYP3A4APPSNCA | |
| Retinol SCHEMBL13449078 | 0.95 | ALDH1A1 (1.00) | ALDH1A1MAPTCYP3A4APPSNCA | |
| Retinol SCHEMBL19660979 | 0.95 | ALDH1A1 (1.00) | ALDH1A1MAPTCYP3A4APPSNCA | |
| Retinol SCHEMBL14619410 | 0.95 | ALDH1A1 (1.00) | ALDH1A1MAPTCYP3A4APPSNCA | |
| Retinol SCHEMBL15593 | 0.95 | ALDH1A1 (1.00) | ALDH1A1MAPTCYP3A4APPSNCA | |
| Retinol SCHEMBL8360234 | 0.95 | ALDH1A1 (1.00) | ALDH1A1MAPTCYP3A4APPSNCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 4480 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122084582-A | Auxiliary kit for detecting content of calcium ions in cells | — | 2026-05-26 | — | — | CN | claimed |
| WO-2026104588-A1 | UROLITHIN COMBINATION | AMAZENTIS SA (CH) | 2026-05-21 | — | — | WO | claimed |
| EP-4745225-A1 | SERUM-FREE NUTRIENT COMPOSITION FOR THE CULTIVATION OF VERTEBRATE CELLS | The Cultivated B. GmbH (DE) | 2026-05-20 | — | — | EP | claimed |
| CN-122056786-A | Lipid hybridization nanoparticle and preparation method and application thereof | 上海世领制药有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-122004361-A | Bullfrog feed composition added with vitamin A and application thereof | 集美大学 | 2026-05-12 | — | — | CN | claimed |
| CN-122005334-A | Polyglycerol-10 oleate nanometer inclusion with particle size smaller than 20nm and natural sources, and preparation method, application and composition thereof | 上海林清轩化妆品集团股份有限公司 | 2026-05-12 | — | — | CN | claimed |
| CN-122004362-A | Tryptophan-added bullfrog feed composition and application thereof | 集美大学 | 2026-05-12 | — | — | CN | claimed |
| US-12624339-B2 | Brain organoid containing optic vesicles generated based on H9 induction and eye-brain fusion culture method | TIANJIN UNIVERSITY (CN) | 2026-05-12 | — | — | US | claimed |
| US-12576046-B2 | Aqueous paediatric retinol formulations | ORPHANIX GMBH (AT) | 2026-03-17 | — | — | US | claimed |
| EP-4483870-B1 | AQUEOUS RETINOL FORMULATIONS | ORPHANIX GMBH (AT) | 2026-02-18 | — | — | EP | claimed |
| EP-0667145-B1 | Stabilized cosmetic or dermatologic composition containing several precursors of a same active agent | OREAL (FR) | 1996-09-25 | — | — | EP | claimed |
| WO-1996004243-A1 | STABLE VITAMIN A | THE PROCTER & GAMBLE COMPANY (US) | 1996-02-15 | — | — | WO | claimed |
| EP-0687172-A1 | SOLID LIPID PARTICLES, PARTICLES OF BIOACTIVE AGENTS AND METHODS FOR THE MANUFACTURE AND USE THEREOF | Pharmacia & Upjohn Aktiebolag (SE) | 1995-12-20 | — | — | EP | claimed |
| EP-0508848-B1 | Cosmetic composition for combatting skin-ageing containing in association at least one retinoid and at least one dialkyl- or trialkylxanthine | OREAL (FR) | 1995-07-19 | — | — | EP | claimed |
| US-5426248-A | Purified vitamin A which has been deodorized and degassed by controlled vacuum heating in absence of light and sparging with inert gas, for foods | THE PROCTER & GAMBLE COMPANY (US) | 1995-06-20 | — | — | US | claimed |
| WO-1994020072-A1 | SOLID LIPID PARTICLES, PARTICLES OF BIOACTIVE AGENTS AND METHODS FOR THE MANUFACTURE AND USE THEREOF | PHARMACIA AB (SE) | 1994-09-15 | — | — | WO | claimed |
| EP-0465343-B1 | Pharmaceutical or cosmetical composition comprising a retinoid and a sterol in association | CIRD GALDERMA (FR) | 1994-06-15 | — | — | EP | claimed |
| WO-1988005653-A1 | TOPICAL COMPOSITION FOR STIMULATING HAIR GROWTH WITH STABLE FREE RADICALS | PROCTOR PETER H (US) | 1988-08-11 | — | — | WO | claimed |
| US-4333924-A | OIL IN WATER EMULSION, MINERAL OIL, LANOLIN, DECYL OLEATE, NONIONIC EMULSIFIER | BEECHAM GROUP LIMITED (GB) | 1982-06-08 | — | — | US | claimed |
| US-4178079-A | Sub-picosecond optical gating by degenerate four-wave mixing | BELL TELEPHONE LABORATORIES, INCORPORATED (US) | 1979-12-11 | — | — | US | claimed |