Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.45 |
| ▸ | TSHR | P16473 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | NPY1R | P25929 | 1/20 | 0.43 |
| ▸ | NPY2R | P49146 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8046719 | 0.77 | ALDH1A1 (0.46) | ALDH1A1TDP1KDM4EHPGDHSD17B10 | |
| SCHEMBL8050246 | 0.76 | ALDH1A1 (0.46) | ALDH1A1TDP1KDM4EHPGDHSD17B10 | |
| SCHEMBL8043960 | 0.73 | L3MBTL1 (0.51) | ALDH1A1TDP1KDM4EHPGDHSD17B10 | |
| SCHEMBL8046056 | 0.73 | ALDH1A1 (0.51) | ALDH1A1TDP1KDM4EHPGDHSD17B10 | |
| SCHEMBL13997161 | 0.72 | L3MBTL1 (0.59) | ALDH1A1TDP1KDM4EHPGDHSD17B10 | |
| SCHEMBL8038016 | 0.72 | HTT (0.46) | ALDH1A1TDP1HSD17B10ALOX15L3MBTL1 | |
| SCHEMBL8043605 | 0.72 | MEN1 (0.45) | ALDH1A1TDP1KDM4EHPGDHSD17B10 | |
| SCHEMBL8044116 | 0.72 | MEN1 (0.43) | ALDH1A1TDP1KDM4EHPGDHSD17B10 | |
| SCHEMBL8045231 | 0.72 | MAPK8 (0.45) | ALDH1A1TDP1KDM4EHPGDHSD17B10 | |
| SCHEMBL8044734 | 0.71 | ALDH1A1 (0.49) | ALDH1A1TDP1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |
| WO-1998027092-A1 | THIAZOLE COMPOUNDS AND METHODS OF MODULATING SIGNAL TRANSDUCTION | SUGEN, INC. (US) | 1998-06-25 | — | — | WO | disclosed |