Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | NPY1R | P25929 | 1/20 | 0.49 |
| ▸ | NPY2R | P49146 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8046056 | 0.89 | ALDH1A1 (0.51) | ALDH1A1LMNASMN1; SMN2TDP1MAPT | |
| SCHEMBL8046031 | 0.80 | ALDH1A1 (0.39) | ALDH1A1LMNASMN1; SMN2TDP1NPY1R | |
| SCHEMBL8046719 | 0.77 | ALDH1A1 (0.46) | ALDH1A1LMNASMN1; SMN2TDP1NPY1R | |
| SCHEMBL8050040 | 0.77 | HTT (0.51) | ALDH1A1LMNASMN1; SMN2MAPTHTT | |
| SCHEMBL8050628 | 0.74 | RAB9A (0.41) | ALDH1A1LMNASMN1; SMN2MAPTHTT | |
| SCHEMBL8050228 | 0.74 | RAB9A (0.41) | ALDH1A1LMNASMN1; SMN2TDP1MAPT | |
| SCHEMBL8043207 | 0.74 | MAPT (0.44) | ALDH1A1LMNASMN1; SMN2MAPTHSD17B10 | |
| SCHEMBL8042281 | 0.74 | GAA (0.41) | ALDH1A1LMNASMN1; SMN2TDP1MAPT | |
| SCHEMBL8041897 | 0.74 | ALDH1A1 (0.47) | ALDH1A1LMNASMN1; SMN2TDP1MAPT | |
| SCHEMBL8044646 | 0.73 | ALDH1A1 (0.52) | ALDH1A1LMNASMN1; SMN2MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |