Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NOS1 | P29475 | 1/20 | 0.48 |
| ▸ | FBP1 | P09467 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.40 |
| ▸ | SELE | P16581 | 1/20 | 0.40 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043894 | 0.81 | GAA (0.49) | PKMSMN1; SMN2NOS1HSD17B10ICAM1 | |
| SCHEMBL8033855 | 0.76 | SMN1; SMN2 (0.33) | NPSR1MAPK1SMN1; SMN2NOS1ALDH1A1 | |
| SCHEMBL8043474 | 0.76 | MEN1 (0.53) | NPSR1MAPK1SMN1; SMN2NOS1ALDH1A1 | |
| SCHEMBL8032615 | 0.76 | SMN1; SMN2 (0.33) | NPSR1MAPK1SMN1; SMN2NOS1ALDH1A1 | |
| SCHEMBL8033099 | 0.75 | MEN1 (0.43) | NPSR1MAPK1SMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL8045097 | 0.75 | RAB9A (0.35) | NPSR1SMN1; SMN2NOS1ALDH1A1KDM4E | |
| SCHEMBL8033022 | 0.73 | ALDH1A1 (0.54) | NPSR1PKMMAPK1PAX8ATM | |
| SCHEMBL8043606 | 0.73 | MEN1 (0.42) | NPSR1MAPK1SMN1; SMN2NOS1ALDH1A1 | |
| SCHEMBL8032831 | 0.72 | MEN1 (0.44) | SMN1; SMN2ALDH1A1NPC1TSHRHTT | |
| SCHEMBL8050068 | 0.72 | MEN1 (0.41) | NPSR1MAPK1SMN1; SMN2ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |