Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.39 |
| ▸ | SELE | P16581 | 1/20 | 0.39 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8043155 | 0.81 | NPSR1 (0.49) | TSHRMAPTPKMNPC1RAB9A | |
| SCHEMBL8043474 | 0.79 | MEN1 (0.53) | GAAGLATSHRMAPTPOLB | |
| SCHEMBL8033855 | 0.79 | SMN1; SMN2 (0.33) | GAAGLATSHRMAPTPOLB | |
| SCHEMBL8032615 | 0.79 | SMN1; SMN2 (0.33) | GAAGLATSHRMAPTPOLB | |
| SCHEMBL8033099 | 0.78 | MEN1 (0.43) | GAAGLATSHRMAPTPOLB | |
| SCHEMBL8045097 | 0.78 | RAB9A (0.35) | GAAGLATSHRMAPTPOLB | |
| SCHEMBL8043606 | 0.76 | MEN1 (0.42) | GAAGLATSHRMAPTPOLB | |
| SCHEMBL8046339 | 0.75 | POLB (0.41) | GAAGLATSHRMAPTPOLB | |
| SCHEMBL8032700 | 0.75 | HTR1A (0.49) | GAAMAPTPKMPOLBNPC1 | |
| SCHEMBL8034279 | 0.75 | HDAC6 (0.45) | GAAMAPTPKMPOLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6080772-A | 2-AMINOTHIAZOLE TRIAZOLE OR TETRAZOLE COMPOUND FOR REGULATING PROTEIN TYROSINE PHOSPHATASE ACTIVITY | SUGEN, INC. (US) | 2000-06-27 | — | — | US | disclosed |